姓名：欧阳敬平

性别：男 

籍贯：湖南省平江县

E-mail：ouyang.jingping@outlook.com

职称：讲师

教育经历：

2013/09-2019/12，博士（硕博连读），药物化学专业，制药工程学院，沈阳药科大学

2009/09-2013/07，学士，制药工程专业，制药工程学院，沈阳药科大学

工作经历：

2024/10-至今，沈阳药科大学，制药工程学院，药物化学教研室，讲师

2021/01-2024/06，博士后，物理、化学和药学系，南丹麦大学

学科/研究方向：

1. 利用生物工程、化学修饰以及材料学等方法修饰蛋白质，构建全新活性的人工酶；

2. 不对称合成方法学及其在手性药物合成中的应用；

教学/指导学生情况：指导本科药物化学实验课、药物合成反应实验课

发表论文：

1. J. Ouyang, et al. Integrating Enzymes with Supramolecular Polymers for Recyclable Photoenzymatic Catalysis. Angew. Chem. Int. Ed. 2024, 63, e202400105. (IF=16.1)

2. J. Ouyang, et al. Artificial Metalloenzymes Enabled by Combining Proteins with Hemin via Protein Refolding. Chin. J. Catal. 2024, 67, 157-165. (IF=15.7)

3. J. Ouyang, J. Li, C. Wu*, Protein-Polymer Conjugates: Advancing Enzyme Catalysis in Synthetic Chemistry, ChemCatChem 2024, e202401180. (IF=3.8)

3. H. Lu, J. Ouyang, et al. Enzyme-Polymer-Conjugate-Based Pickering Emulsions for Cell-Free Expression and Cascade Biotransformation. Angew. Chem. Int. Ed. 2023, 62, e202312906. (IF=16.6)

4. J. Guo, R. Zhang, J. Ouyang, F. Zhang, F. Qin, G. Liu, W. Zhang, H. Li, X. Ji, X. Jia, B. Qin and S. You. Stereodivergent Synthesis of Carveol and Dihydrocarveol through Ketoreductases/Ene-Reductases Catalyzed Asymmetric Reduction. ChemCatChem, 2018, 10, 5496-5504. (IF=4.495)

5. F. Qin, B. Qin, W. Zhang, Y. Liu, X. Su, T. Zhu, J. Ouyang, J. Guo, Y. Li, F. Zhang, J. Tang, X. Jia and S. You. Discovery of a Switch Between Prelog and Anti-Prelog Reduction toward Halogen-Substituted Acetophenones in Short-Chain Dehydrogenase/Reductases. ACS Catalysis, 2018, 8, 6012-6020. (IF=12.221)

6. J. Ou-Yang, W. Zhang, F. Qin, W. Zuo, S. Xu, Y. Wang, B. Qin, S. You and X. Jia. Enantioselective bioreduction of benzo-fused cyclic ketones with engineered Candida glabrata ketoreductase 1 - A promising synthetic route to ladostigil (TV3326). Organic & biomolecular chemistry, 2017, 15, 7374-7379. (IF=3.49)

7. J. Ou-Yang, Y. Zhao, H. Jiang, L. Meng, X. Li and X. Jia. A Simple, One-Pot Synthesis of Trans-Substituted Spiro [5,5] undecane-1,5,9-triones with Aromatic Aldehydes and Meldrum’s Acid as the Starting Materials. Australian Journal of Chemistry, 2015, 68, 1599-1602. (IF=1.226)

8. B. Qin, Y. Li, L. Meng, J. Ouyang, D. Jin, L. Wu, X. Zhang, X. Jia and S. You, "Mirror-image" manipulation of curdione stereoisomer scaffolds by chemical and biological approaches: development of a sesquiterpenoid library. Journal of natural products, 2015, 78, 272-278. (IF=4.257)

9. G. Ma, Z. Xu, P. Zhang, J. Liu, X. Hao, J. Ouyang, P. Liang, S. You and X. Jia. A Novel Synthesis of Rasagiline via a Chemoenzymatic Dynamic Kinetic Resolution. Organic Process Research & Development, 2014, 18, 1169-1174. (IF=3.327)

10. J. Wang, J. Ouyang, Y. Liu, X. Jia, S. You, X. He and X. Di, Development of a sensitive LC-MS/MS method for the determination of bilobalide in rat plasma with special consideration of ex vivo bilobalide stability: application to a preclinical pharmacokinetic study. Journal of Pharmaceutical and Biomedical Analysis, 2014, 95, 238-244. (IF=2.983)