姓名：侯状

性别：男

籍贯：四川阆中

联系电话：18002429062

E-Mail：houzhuang8@sina.com

职称/职务：副教授

通讯地址：辽宁省本溪市高新技术产业开发区华佗大街26号

办公地点：南校区制药楼425室

教育经历：2014/09－2017/06，沈阳药科大学，制药工程学院，博士

2012/09－2014/06，沈阳药科大学，制药工程学院，硕士

2008/09－2012/06，沈阳药科大学，工商管理学院，学士

工作经历：2019/12 -至今，沈阳药科大学，制药工程学院，副教授

2017/12 -2019.12，沈阳药科大学，制药工程学院，讲师

2017/08 -2017/12，沈阳药科大学，制药工程学院，助教

兼职情况：无

学科/研究方向：研究方向一：基于靶点结构的抗青光眼、抗肿瘤及抗糖尿病药物研究

研究方向二：药物合成新工艺研究

科研/获奖情况： 辽宁省百千万人才工程“万人层次”，沈阳市高层次人才

教学/指导研究生情况： 讲授药物化学课程，指导本科药物化学实验课、药物合成反应实验课、化学制药工艺学实验课

发表论文/出版著作：

代表性著作：无

代表性论文：

1. Hang Xu, Zhong-zuo Yan, Meng-bi Guo, Ran An, Xin Wang, Rui Zhang,Yan-hua Mou, Zhuang Hou*, Chun Guo*. Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. European Journal of Medicinal Chemistry. 2021, 216, 113337. (IF=5.572)

2. Hang Xu, Xin Su, Meng-bi Guo, Ran An, Yan-hua Mou, Zhuang Hou*, Chun Guo*. Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. European Journal of Medicinal Chemistry. 2020, 198, 112360. (IF=5.572)

3. Shuang Hao, Xue Cheng, Xin Wang, Ran An, Hang Xu, Mengbi Guo, Chuanchao Li, Yitong Wang, Zhuang Hou*, Chun Guo*. Design, synthesis and biological evaluation of novel carbohydrate-based sulfonamide derivatives as antitumor agents. Bioorganic Chemistry. 2020, 104, 104237. (IF=4.831)

4. Ran An, Bin Lin, Shuang Zhao, Chun Cao, Yuanxin Wang, Xue Cheng, Yichuang Liu,Mengbi Guo, Hang Xu, Yitong Wang, Zhuang Hou*, Chun Guo*. Discovery of novel artemisinin-sulfonamide hybrids as potential carbonic anhydrase IX inhibitors with improved antiproliferative activities. Bioorganic Chemistry. 2020, 104, 104347. (IF=4.831)

5. Shuang Hao, Zhuang Hou*, Chun Guo*. Sequential one-pot synthesis of (1→6) amide-linked oligosaccharide mimetics under mild conditions. Journal of Carbohydrate Chemistry. 2020, 39, 267. (IF=0.85)

6. Ran An, Zhuang Hou*, Chun Guo*. Recent advances in synthesis of benzazoles via imines. Current Organic Chemistry. 2020, 24, 1. (IF=1.92)

7. Dongpo Cao, Kaipeng Zhang, Ran An, Hang Xu, Shuang Hao, Xiaoguang Yang, Zhuang Hou*, Chun Guo*. The Efficient Synthesis of Benzannulated Seven-Membered OHeterocycles via the Intramolecular Ring-Opening Cyclization of Cyclopropanes. Organic Letters, 2019, 21, 8948. (IF=6.555)

8. Zhuang Hou, Chuanchao Li, Yichuang Liu, Miao Zhang, Yitong Wang, Zhanfang Fan, Chun Guo, Bin Lin and Yang Liu. Design, synthesis and biological evaluation of carbohydrate-based sulfonamide derivatives as topical antiglaucoma agents through selective inhibition of carbonic anhydrase II. Journal of Enzyme Inhibition and Medicinal Chemistry. 2019, 1, 383-390. (IF=4.673)

9. Haonan Yu†, Zhuang Hou†, Xiaoguang Yang, Yanhua Mou, Chun Guo. Design, Synthesis, and Mechanism of Dihydroartemisinin-Coumarin Hybrids as Potential Anti-Neuroinflammatory Agents. Molecules, 2019, 24, 1672. (IF=3.06)

10. Hang Xu, Xin Su, Xiao-qian Liu, Kai-peng Zhang, Zhuang Hou*, Chun Guo*. Design, synthesis and biological evaluation of novel semicarbazoneselenochroman-4-ones hybrids as potent antifungal agents. Bioorganic & Medicinal Chemistry Letters. 2019, 29, 126726. (IF=2.448)

11. Hang Xu†, Zhuang Hou†, Zhen Liang, Meng-Bi Guo, Xin Su,, Chun Guo. Design, synthesis and antifungal activity of Benzofuran and the its analogues. Chinese Journal of Chemistry. 2019, 37, 1245. (IF=3.576)

12. Ran An†, Zhuang Hou†, Jian-Teng Li, Hao-Nan Yu, Yan-Hua Mou and Chun Guo. Design, Synthesis and Biological Evaluation of Novel 4-Substituted Coumarin Derivatives as Antitumor Agents. Molecules, 2018, 23, 2281. (IF=3.06)

13. Dan-Jiao Wang†, Zhuang Hou†, Hang Xu, Ran An, Xin Su, Chun Guo. Design, synthesis, and biological evaluation of 4-chloro-2H-thiochromenes. Bioorganic & Medicinal Chemistry Letters. 2018, 28, 3574. (IF=2.448)

14. Haonan Yu†, Zhuang Hou†, Ye Tian, Yanhua Mou, Chun Guo, Design, synthesis, cytotoxicity and mechanism of novel dihydroartemisinin-coumarin hybrids as potential anti-cancer agents. European Journal of Medicinal Chemistry. 2018, 151, 434. (IF=4.833)

15. Zhuang Hou, Bin Lin, Yu Bao, Hai-ning Yan, Miao Zhang, Xiao-wei Chang, Xin-xin Zhang, Zi-jie Wang, Gao-fei Wei, Mao-sheng Cheng, Yang Liu, Chun Guo. Dual-tail approach to discovery of novel carbonic anhydrase IX inhibitors by simultaneously matching the hydrophobic and hydrophilic halves of the active site. European Journal of Medicinal Chemistry, 2017, 132, 1. (IF=4.519)

16. Zhuang Hou, Yang Liu, Xin-xin Zhang, Xiao-wei Chang, Mao-sheng Cheng, Chun Guo. Synthesis of glucuronic acid derivatives via the efficient and selective removal of a C6 methyl group. Tetrahedron Letters, 2017, 58, 423. (IF=2.347)

中国发明专利

1. 刘洋，程卯生，侯状等N-4-苯磺酰胺基-N’-1-脱氧-β--吡喃葡萄糖醛酸基-硫脲化合物的制备方法及医药用途.ZL 201310690696.0

2. 刘洋，郭春，侯状，程卯生等N-4-苯磺酰胺基-N’-1-脱氧-(2-脱氧-2-取代氨基)-β-D-吡喃葡萄糖基硫脲化合物及其用途.ZL 201610718089.4

3. 刘洋，郭春，侯状，程卯生等具有葡萄糖醛酸结构的磺酰胺类化合物的制备方法及医药用途.ZL 2017114190560

4. 郭春，侯状等抗真菌剂-含1,2,3-三氮唑结构的烯醇醚类化合物.ZL 2018103242706

5. 刘洋，侯状等一类带有香豆素和糖基结构的磺胺化合物的制备方法及医药用途. ZL 202110294548.1

6. 侯状，郭春等含磺酰胺结构的喹啉类化合物的制备方法及医药用途. ZL 202110294936.X