姓名:刘明哲
性别:男
籍贯:辽宁省沈阳市
联系电话:15940120642
E-Mail:prcmzliu@sohu.com
职称/职务:副教授
通讯地址:辽宁省本溪经济技术开发区(石桥子镇)华佗大街26号沈阳药科大学南校区24号信箱
办公地点:沈阳药科大学南校区制药工程学院楼237室
教育经历:
2003/4 - 2006/3,东京大学,工学院化学与生物技术专业,博士
2001/4 - 2003/3,东京大学,工学院化学与生物技术专业,硕士
2000/4 – 2001/3,东京大学,工学院化学与生物技术专业,大学院研究生
1998/11 - 2000/3,日本国飞鸟学院,日语研修生
1992/9 - 1996/6,天津大学,应用化学系精细化工专业,学士
1992/9 - 1996/6,天津大学,管理系工业管理工程专业,双学士
工作经历:
2011/6 - 至今,沈阳药科大学,制药工程学院有机化学教研室,副教授
2006/4 - 2011/4,日本理化学研究所(RIKEN),合同制研究员
2007/4 - 2010/3,日本理化学研究所(RIKEN),基础科学特别研究员
2006/9 - 2007/3,日本学术振兴会(JSPS),特别研究员
1996/7 - 1998/10,天津乐金精密化工有限公司,职员
兼职情况:
中国药学会会员,中国化学会会员,中国生物材料学会会员,日本化学会会员,
日本理化学研究所(RIKEN)客座研究员,Bioorg. Med. Chem. Lett.,J. Mater. Chem. B等期刊审稿人
学科/研究方向:
药物化学,生物有机化学,生物材料
科研/获奖情况:
1. 刘明哲,赵海旭,蒋刚锋,翁金鹏,A Signal-accumulating DNAzyme-crosslinked hydrogel for colorimetric sensing of hydrogen peroxide,辽宁省自然科学学术成果奖(学术论文类),二等奖,2017.09.19
2. 刘明哲,In vitro selection of a photo-responsive peptide aptamer using ribosomedisplay,2013年辽宁省自然科学学术成果奖(学术论文类),二等奖,2013.08.02
教学/指导研究生情况:
指导硕士研究生18人,其中合作指导2人,已毕业7人。指导本科毕业专题生30名,其中毕业26名。
发表论文/出版著作:
代表性著作:
1. Hara S., Liu Mingzhe, Wang W., Xu M. Y., Li Z., and Ito Y., “Stabilized ribosome display for in vitro selection”, in “Ribosome Display and Related Display Technologies: Methods and Protocols”, “Methods in Molecular Biology”, ed by Julie Douthwaite and Ron Jackson, Humana Press, Cambridge, p.59-73, (2011)
2. Liu, Mingzhe; Abe, H.; Ito, Y., “Hemin-Binding Aptamers and Aptazymes”, Green Polymer Chemistry: Biocatalysis and Biomaterials, Cheng, H. N.; Gross, R. A., Eds., American Chemical Society: Washington, DC, 2010, 111-123.
3. Ito, Y.; Abe, H.; Wada, A.; Liu, Mingzhe, “Design and synthesis of biorelated polymers by combinatorial bioengineering”, Polymer biocatalysis and biomaterials II, ACS Symp. Ser., 2008, 999 194-215.
代表性论文:
1. Jiang, G.; Weng, J.; Kong, L.; Xu, H.; Liu Mingzhe* “Reduction-sensitive N,N'-dimethacryloylcystine nanohydrogel for triggered drug release”, Materials Letters, 2017, 189, 122-125. (IF=2.437)
2. Zhao, H.; Jiang, G.; Weng, J.; Ma, Q.; Zhang, H.; Ito, Y. and Liu, Mingzhe* “A Signal-accumulating DNAzyme-crosslinked hydrogel for colorimetric sensing of hydrogen peroxide”, Journal of Materials Chemistry B, 2016, 4, 4648-4651. (IF=4.872)
3. Liu, Mingzhe; Tada, S.; Ito, M.; Abe, H.; Ito, Y.*“In vitro selection of a photo-responsive peptide aptamer using ribosome display”Chemical Communications, 2012, 48, (97), 11871-11873. (IF=6.567)
4. Liu, Mingzhe; Xu, M. Y.; Loh, X. J.; Abe, H.; Tsumuraya, T.; Fujii, I.; Li, J.; Son, T. I.; Ito, Y.* “PEGylated antibody in organic media” Journal of Bioscience and Bioengineering, 2011, 111, (5), 564-568. (IF=1.964)
5. Liu, Mingzhe; Jinmei, H.; Abe, H.; Ito, Y. *“In Vitro Selection of a Photoresponsive RNA Aptamer to Hemin”, Bioorganic & Medicinal Chemistry Letters, 2010, 20, (9), 2964-2967. (IF=2.486)
6. Liu, Mingzhe; Kagahara, T.; Abe, H.; Ito, Y. * “In vitro selection of hemin-binding catalytic RNA”, Bioorganic & Medicinal Chemistry Letters, 2009, 19, (5), 1484-1487. (IF=2.486)
7. Liu, Mingzhe; Kagahara, T.; Abe, H.; Ito, Y. * “Direct In Vitro Selection of Hemin-Binding DNA Aptamer with Peroxidase Activity”, Bulletin of the Chemical Society of Japan, 2009, 82, (1), 99-104. (IF=1.372)
8. Liu, Mingzhe; Jinmei, H.; Abe, H.; Ito, Y. * Chemical aminoacylation of RNA by an intermolecular adenosine transfer reaction. Chemistry Letters, 2008, 37, (1), 102-103. (IF=1.55)
9. Liu, Mingzhe; Asanuma, H. *; Komiyama, M., “Azobenzene-tethered T7 promoter for efficient photoregulation of transcription”, Journal of the American Chemical Society, 2006, 128, (3), 1009-1015. (IF=13.038)