姓名：陈国良

性别：男

籍贯：湖南省攸县

联系电话：13940195895

E-Mail：spucgl@163.com

职称/职务：教授

通讯地址：辽宁省沈阳市文化路103号

办公地点：辽宁省本溪市溪湖区沈阳药科大学南校区

教育经历：

1983.09-1986.06  湖南省卫生学校 药剂专业 中专

1990.09-1993.06  沈阳药科大学 药物化学硕士研究生

1999.09-2005.12  沈阳药科大学 药物化学博士研究生

2000.09-2001.07  北京语言大学出国部 学习法语

工作经历：

1986.06-1990.08  化工部湘东化工机械厂职工医院 药剂师

1993.09-2000.08  沈阳药科大学制药工程学院 讲师

2001.11-2002.11  瑞士弗莱堡大学化学系 访问学者

2002.11-2012.12  沈阳药科大学制药工程学院 副教授

2012.12-今 沈阳药科大学制药工程学院 教授

兼职情况：

1. 沈阳药科大学学报编委

2. 中国药物化学杂志编委

3. 国家自然基金通讯评议人

4. 国家发改委药品价格司药品价格评审专家

5. 辽宁省、浙江省、江苏省自然基金评审专家

学科/研究方向：抗癌药物研发；神经退行性疾病治疗药物研发；专利过期药品及功能性分子合成工艺研究

科研/获奖情况：

泰山产业领军人才 山东省人民政府 2018.12

教学/指导研究生情况：

药物化学理论课及药物化学实验、药物合成反应实验

已毕业硕士研究生60多人和博士生一名，目前在读硕士生21名，博士生4名

发表论文/出版著作：

代表性著作：

1. 十二五规划教材 制药工程导论 参编 人民卫生出版社 2014年

2. 高等院校药学与制药工程专业规划教材 药物合成反应 副主编 浙江大学出版社 2010年

代表性论文：

近5年发表的SCI论文有:

Fangyu Du, Qifan Zhou, Xiaoxiao Fu, Yajie Shi, Yuanguang Chen, Wuhong Fang, Jingyu Yang*, Guoliang Chen*. Synthesis and biological evaluation of 2,2- dimethylbenzopyran derivatives as potent neuroprotection agents. RSC Advances, 2019, 9(5): 2498-2508. IF 2.936

Fangyu Du, Qifan Zhou, Yajie Shi, Miao Yu, Wenjiao Sun, Guoliang Chen*. A new pathway via intermediate 4-amino-3-fluorophenol for the synthesis of regorafenib. Synthetic Communication, 2019, 49(4): 576-586. IF 1.377

Xuefei Bao, Yuhong Sun(共同第一作者), changshun Bao, Jiayu Zhang, Shenglan Zou, Jingyu Yang, Chunfu Wu, Lihui Wang*, Guoliang Chen*. Design, synthesis and evaluation of N-hydroxypropenamides based on adamantane to overcome resistance in NSCLC. Bioorganic Chemistry, 2019, 86(5): 696-704. IF 3.929

Dong L, You S, Zhang Q, Osuka S, Devi NS, Kaluz S, Ferguson JH, Yang H, Chen G, Wang B, Grossniklaus HE, Van Meir EG*. Arylsulfonamide 64B Inhibits Hypoxia/HIF-Induced Expression of c-Met and CXCR4 and ReducesPrimary Tumor Growth and Metastasis of Uveal Melanoma. Clin Cancer Res. 2019 Apr 1;25(7): 2206-2218. IF 10.199

Fangyu Du, Qifan Zhou, Dongdong Liu, Ting Fang, Yajie Shi, Yang Du, Guoliang Chen^*. Dimerization of aromatic compounds using palladium-carbon catalyzed Suzuki-Miyaura cross-coupling by One-Pot. Synlett, 2018, 29: 799-784. IF2.369

Qifan Zhou, Peng Chen, Fangyu Du, Linbo Zhou, Yajie Shi, Yang Du, Dongdong Liu, Wenjiao Sun, Meixia Zhang^*, Guoliang Chen^*. Design, Synthesis and Activity of BBI608 Derivatives Targeting on Stem Cells. Euro J Med Chem, 2018, 151(3): 39-50. IF 4.816

Qifan Zhou, Fangyu Du, Xinjie Liang, Wenqiang Liu, Ting Fang, Guoliang Chen *. Zinc (II)-Mediated Selective O-Benzylation of 2-Oxo-1,2-dihydropyridines Systems. Molecules, 2018, 23(7): 1784. IF 3.098

Qifan Zhou, Fangyu Du, Yajie Shi, Wenqiang Liu, Dongdong Liu and Guoliang Chen*. An efficient protocol for the production of pymetrozine via a new synthetic strategy. Journal of Chemical Research, 2018, 42(8): 434-438. IF 0.668

Chunling Yuan, Xiaoli Guo, Qifan Zhou, Fangyu Du, Wei Jiang, Xiaoyu Zhou,Peng Liu, Tianyan Chi, Xuefei Ji, Jinheng Gao, Chengwen Chen, Hongli Lang, Jia Xu, Danyang Liu, Yang Yang, Shimeng Qiu, Xing Tang, Guoliang Chen^⁎, Libo Zou^⁎. OAB-14, a bexarotene derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice. BBA - Molecular Basis of Disease, 2019, 1865(1): 161–180. IF 5.108

Qifan Zhou, Fangyu Du, Yajie Shi, Ting Fang, Guoliang Chen*. Synthesis and analysis of 1-methyl-4-phenyl-1H-imidazol-2-amine. Journal of Chemical Research, 2018, 42(12): 608-610. IF 0.668

Xuefei Bao, Xuejun Qiao, Changshun Bao, Yuting Liu, Xuan Zhao, Yi Lu, and Guoliang Chen*. Synthesis of Tamibarotene via Ullmann-Type Coupling. Organic Process Research & Development. 2017, 21(4): 748-753. IF 2.857

Xuefei Bao, Ziao Liu, Xinjie Liang, Dake Song, Tao Shi, Xuan Zhao, Changshun Bao, Guoliang Chen*. Synthesis of 3-Formylbenzenesulfonyl Chloride Derivatives. Synthesis, 2017, 49(5):3165-3170. IF2.650

Lihui Wang, Huahuan Li, Yong Ren, Shenglan Zou,Wuhong Fang, Xiaorui Jiang, Lina Jia, Meng Li, Xing Liu, Xiangzhong Yuan, Guoliang Chen^*, Jingyu Yang^*, Chunfu Wu^*. Targeting HDAC with a Novel Inhibitor Effectively Reverses Paclitaxel Resistance in Non–Small Cell Lung Cancer via Multiple Mechanisms. Cell death & disease, 2016, 7, e2063, doi: 10.1038/cddis.2015.328  IF 5.965

Xuejun Qiao, Xiao Hou, Wuhong Fang, Xuefei Bao, Guoliang Chen^*. An Efficient and Chemoselective Deprotection of Aryl tert-Butyldimethylsilyl (TBDMS) Ethers by NaCN. J Braz Chem Soc, 2016, 27(5): 899-904. IF 1.444

Lihui Wang, Xuefei Bao, Jingyu Yang, Huahuan Li, Qifan Zhou, Xiaorui Jiang, Meng Li , Xing Liu, Xiangzhong Yuan, Guoliang Chen ^* , Chunfu Wu ^*. Novel cinnamohydroxamic acid derivatives as HDAC inhibitors with anticancer activity in vitro and in vivo. Chemico-Biological Interactions, 2016, 249: 64-70. IF 3.1419

Xuefei Bao, Dake Song, Xuejun Qiao, Xuan Zhao, Guoliang Chen*. The Development of an Effective Synthetic Route of Belinostat, Organic Process Research and Development, 2016, 20(8): 1482-1488. IF 3.584

Xuefei Bao, Xuejun Qiao, Xiao Hou, Wuhong Fang, Xuelong Liu, Guo-liang Chen*. A One-Pot Domino Synthesis of 5-(Trifluoromethyl)-2-thiazolamine. J Braz Chem Soc, 2016, 27(12), 2388-2391. IF 1.444

Wang LH, Jiang XR, Yang JY, Bao XF, Chen JL, Liu X, Chen GL*, Wu CF*. SYP-5, a novel HIF-1 inhibitor, suppresses tumor cells invasion and angiogenesis. Eur J Pharmacol. 2016;791:560-568.  IF 2.73

Lihui Wang, Guoliang Chen(共同第一作者), Xiuhong Lu, Shuang Wang, Shanghe Han, Yi Li, Guanfang Ping, Xiaorui Jiang, Huahuan Li, Jingyu Yang^*,Chunfu Wu^*. Novel chalcone derivatives as hypoxia-inducible factor (HIF)-1 inhibitor: Synthesis, anti-invasive and anti-angiogenic properties. European Journal of Medicinal Chemistry, 2015, 89(1): 88-97. IF 4.816

Wang LH, Chen GL, Chen Kang, Ren Y, Fu SY, Li Y, Liu XW, Wang S, Yang JY*, Wu CF*. Dual Targeting of Retinoid X Receptor and Histone Deacetylase with DW22 as a Novel Antitumor Approach. Oncotarget, 2015, 6(12): 9740-9755.(IF 6.627).

Mao J, Huang S, Liu S, Feng XL, Yu M, Liu J, Sun YE, Chen G, Yu Y, Zhao J1, Pei G. A herbal medicine for Alzheimer's disease and its active constituents promote neural progenitor proliferation. Aging Cell, 2015, 14(5):784-65. IF 6.34

Wang LH, Li HH, Li M, Wang S, Jiang XR, Li Y, Ping GF, Cao Q, Liu X, Fang WH, Chen GL, Yang JY, Wu CF. SL4, chalcone-based compound, induces apoptosis in human cancer cells by activation of the ROS/MAPKsignalling pathway. Cell Prolif, 2015, 48(6): 718-728. IF 4.936