姓名：胡春

性别：男

籍贯：江苏省沭阳县

联系电话：024-43520246

E-Mail：chunhu1999@163.com

职称/职务：教授

通讯地址：沈阳市沈河区文化路103号

办公地点：制药楼205房间

教育经历：

1981.9-1985.7，江苏师范大学化学专业本科生

1985.9-1988.6，东北师范大学有机化学专业硕士生

1993.9-1999.1，沈阳药科大学药物化学专业博士生

工作经历：

1988.7-现在，沈阳药科大学制药工程学院教师

兼职情况：

学科/研究方向：

靶向药物的研究与开发、药物合成工艺研究、医药中间体的研究和杂环化学研究

科研/获奖情况：

2014年沈阳市科学技术进步二等奖

2015年辽宁省科学技术进步三等奖

教学/指导研究生情况：

近5年来，讲授本科生“有机化学”合计560标准学时，“精细化学品化学”合计160标准学时，研究生“化学信息学”合计200标准学时，指导药物化学专业、有机化学专业、应用化学专业硕士研究生合计25人，指导药物化学专业博士研究生4人。

发表论文/出版著作：

代表性著作：

胡春主编，有机化学，高等教育出版社，2012年

胡春主编，有机化学，第二版，中国医药科技出版社，2013年

代表性论文：
• Si-Jie Liu, Li-Bo Cui, Hiu-Lan Xu, Tie-Ying Wang, Chun Hu, Shuo Li, Huang-Quan Lin, and David Chicheong Wan. Design, Synthesis, and Biological Evaluation of 7H- Thiazolo[3,2-b]-1,2,4-triazin-7-one Derivatives as Dual Binding Site Acetylcholinesterase Inhibitors. Heterocycles, 2013, 87(12): 2607-2614.

• Jianshu Hu, Wei Zhu, Hu Meng, Ying Liu, Xin Wang and Chun Hu. Identification of 1, 4-Dihydrothieno[3′, 2′:5, 6]thiopyrano[4, 3-c]pyrazole Derivatives as Human 5-Lipo-oxygenase Inhibitors. Chemical Biology and Drug Design, 2014, 84(6): 642–647.

• Xin Wang, Rui Sun, Yushu Huang, Yisi Yan, Miaomiao Gao, Danni Wang, Diwa Koirala, Dawei Li, Chun Hu. Development of Thieno[3',2':5,6]thiopyrano[4,3- c]pyrazole-3-carboxamide Derivatives as the Estrogen Receptor Ligands: Synthesis, Characterization and Biological Activity. Medicinal Chemistry, 2014, 10(8): 836-942.

• Xiao-ping Liu, Hui-lan Xu, Rui Sun, Xue Li, Bao-hua Hu, Chun Hu. Synthesis and Characterization of Two Impurities in Esomeprazole, an Antiulcerative Drug. Latin American Journal of Pharmacy, 2015, 34(6): 1265–1268.

• Bing Sun, Xiu’e Yin, Jin Zhang, Jian Huang, Yue Xu, Furong Zhang, Jinhui Wang, Guoqing qing Wang, Chun Hu. Synthesis, Characterization and Biological Activity of Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine Derivatives as Epidermal Growth Factor Receptor Inhibitors. Chemical Research in Chinese Universities, 2015, 31(6): 936-941.

• Bing SUN, Jin ZHANG , Xiu’e YIN, Yue XU, Furong ZHANG, Yushu HUANG, Jinhui WANG, Guoqing WANG & Chun HU. Synthesis, Characterization and Biological Activity of thieno[2,3-d]pyrimidine Derivatives as the Epidermal Growth Factor Receptor Inhibitors. Latin American Journal of Pharmacy, 2016, 35(3): 570- 577.

• LI Han-Yue, HAN Yu, JIN Zhe, WANG Shi-Hui, LI Xin-Zeng, LIU Si-Yu, HU Chun. The Crystal Structure of 3-(4-methoxyphenyl)-2-(4-methylbenzoyl)-6,7- dihydro-5H-furo[3,2-g]chromene. Chinese Journal of Structural Chemistry, 2016, 35(4): 545-549.

• Gang Li, Liang Zhao, Peng Yang, Zhaozheng Yang, Zhangmin Tian, Yan Chen, Hongyan Shen, and Chun Hu. Engineering 1,3-Alternate Calixcarbazole for Recognition and Sensing of Bisphenol F in Water. Anal Chem. 2016 , 88(21):10751- 10756.

• ZHANG Lan, DENG Xinshan, WU Jiaofeng, MENG Guangpeng, LIU Congchong, CHEN Guzhou, ZHAO Qingchun, HU Chun. Design, Synthesis and Biological Activities of N-(Furan-2-ylmethyl)-1H-indole-3-carboxamide Derivatives as Epidemal Growth Factor Receptor Inhibitors and Anticancer Agents. Chemical Research in Chinese Universities, 2017, 33(3): 365-372.

• Lan Zhang, Xin-Shan Deng, Chao Zhang, Guang-Peng Meng, Jiao-Feng Wu, Xue- Song Li, Qing-Chun Zhao, Chun Hu. Design, synthesis and cytotoxic evaluation of a novel series of benzo[d]thiazole-2-carboxamide derivatives as potential EGFR inhibitors. Medicinal Chemistry Research, 2017, 26(9):2180-2189.

• Wenjing Ye, Xiao Xiao, Lan Wang, Shicheng Hou, Chun Hu. Synthesis of mono- and binuclear Cu(ii) complexes bearing unsymmetrical bipyridine–pyrazole–amine ligand and their applications in azide–alkyne cycloaddition. Organometallics, 2017, 36 (11): 2116–2125.

• Dongming Yao, Yichu Liu, Shiqiang Yan, Yingxia Li, Chun Hu, Ning Ding. Evidence of robust participation by an equatorial 4-o group in glycosylation on a 2- azido-2-deoxy-glucopyranosyl donor. Chemical Communications, 2017, 53(20): 2986-2989.

• Lan Zhang, Cong-Chong Liu, Gu-Zhou Chen, Xu-Liang Jiang, Qing-Chun Zhao, Chun Hu. Design, Synthesis and Biological Evaluation of a Novel Series of Indole-3- Carboxamide Derivatives for Cancer Treatment as EGFR Inhibitors. Letters in Drug Design & Discovery, 2018, 15(1): 70-83.

• Shicheng Hou, Henan Xu, Jianshu Hu, Jian Hou, Yan Wang, Zhe Jin, David C.C. Wan, Chun Hu. Synthesis, β-catenin Translocation Capability and ALP Activation Activity of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one Derivatives. Medicinal Chemistry, 2018, 14(1): 67-73.

• Chun-Yeung Lo, Olive Tin-Wai Li, Wen-Ping Tang, Chun Hu, Guo Xin Wang, Jacky Chi-Ki Ngo, David Chi-Cheong Wan, Leo Lit-Man Poon & Pang-Chui Shaw. Identification of influenza polymerase inhibitors targeting C-terminal domain of PA through surface plasmon resonance screening. Scientific Reports, 2018, 8: 2280.

• Jia Ke, Qi Lu, Xin Wang, Rui Sun, Zhe Jin, Xiaoyi Zhan, Jianshu Hu, David Chi-cheong Wan, Chun Hu. Discovery of 4,5-Dihydro-1H-thieno[2’,3’:2,3]thiepino[4,5-c]pyrazole-3-carboxamide Derivatives as the Potential Epidermal Growth Factor Receptors for Tyrosine Kinase Inhibitors. MOLECULES, 2018, 23(8): 1980.

• Jia Ke, Xin-Shan Deng, Jin-Long Li, Yong-Peng Li,Yuan-Yuan Niu, Shao-Li Wang, Xiao-Ping Liu, Chun Hu. Synthesis and Characterization of Two Impurities in (S)-Pantoprazole as a Chiral Proton Pump Inhibitor. Latin American Journal of Pharmacy, 2018, 37(8): 1668-1671.

• Xianglai Liu, Sumei Ren, Qi Gao, Chun Hu, Yingxia Li, and Ning Ding. Glycosylation of a Ketone with an O-Glycosyl Trichloroacetimidate Provides an Enol Glycoside. Organic Letters, 2018, 20, 5186-5189.

• Liang Zhao, Le Kang, Yan Chen, Gang Li, Lan Wang, Chun Hu, Peng Yang. Spectral study on conformation switchable cationic calix[4]carbazole serving as curcumin container, stabilizer and sustained-delivery carrier. Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy, 2018, 193: 276-282.

• Gang Li, Xiaoyu Song, Hui Yu, Chun Hu, Mingzhe Liu, Jie Cai, Liang Zhao, Yan Chen, Peng Yang.  Supramolecular recognition of A-tracts DNA by calix[4]carbazole.  Sensors and Actuators B: Chemical, 2018, 259 : 177-182.