姓名：王健

性别：男

籍贯：内蒙古

联系电话：18341401082

E-Mail：18341401082@139.com

职称/职务：副教授

通讯地址：沈阳药科大学

办公地点：制药楼225

教育经历：2004-2009 沈阳药科大学，博士研究生

工作经历： 2009-今 沈阳药科大学，副教授

兼职情况：无

学科/研究方向：药物化学/计算机辅助药物设计

科研/获奖情况： 承担国家自然科学基金1项

教学/指导研究生情况： 《计算机辅助药物设计》

发表论文/出版著作： 发表SCI收录论文121篇。

代表性著作：无

代表性论文：

1. Li, H.; Zhang, Z.; Yang, X.; Mao, X.; Wang, Y.; Wang, J.; Peng, Y.; Zheng, J. Electron deficiency of nitro group determines hepatic cytotoxicity of nitrofurantoin. Chemical research in toxicology 2019.

2. Sun Mengchi,Zhang Xiangyu,Gao Zisen et al. Probing a dipeptide-based supramolecular assembly as an efficient camptothecin delivering carrier for cancer therapy: computational simulations and experimental validations.[J] .Nanoscale, 2019.

3. Chengjun Wu, WeibinXie, Linwei Li, Wei Li, Jian Wang*, Tiemin Sun*. Spectroscopic investigations and molecular docking analysis of ML115: A potential molecular probe of the signal transducer and activator of transcription. Journal of Molecular Structure, 2019, 1175: 638-647. DOI: 10.1016/j.molstruc.2018.08.035.

4. Chao Ma, Baichun Hu, Linkui Zhang, Ying Zhao, Mingxing Wang, Jian Wang*, MaoshengCheng. Computational investigation of the antagonism effect towards GluN2B-Containing NMDA receptor: Combined ligand-based and target-based approach. Journal of Molecular Graphics and Modelling. 2019, 86: 95-105.

5. Yudan Wang, MengtianJia, Xia Wu, Ting Wang, Jian Wang*, XiaohongHoub. PEG modified column MIL-101(Cr)/PVA cryogelas a sorbent in stir bar solid phase extraction for determination of non-steroidal anti-inflammatory drugs in water samples. Microchemical Journal 2019，146: 214–219.

6. GuihuaGao, Yanyan Xing, Tingting Liu, Jian Wang*, XiaohongHou. UiO-66(Zr) as sorbent for porous membrane protected micro-solid-phase extraction androgens and progestogens in environmental water samples coupled with LC-MS/MS analysis: The application of experimental and molecular simulation method.Microchemical Journal 2019，146:126–133.

7. Zhaokun Wang, JunyuanZhang ,Baichun Hu, Jia Yu, Jian Wang*, XingjieGuo. Graphene/Fe 3 O 4 nanocomposite for effective removal of ten triazole fungicides from water solution: Tebuconazole as an example for investigation of the adsorption mechanism by experimental and molecular docking study. Journal of the Taiwan Institute of Chemical Engineers 2019, in press.

8. Jing Xing, Zhenlong Yu, Xiangyu Zhang, Wenyang Li, Dongna Gao, Jian Wang, Xiaochi Ma, XinshiNie, Wei Wang. Epicatechin alleviates inflammation in lipopolysaccharide-induced acute lung injury in mice by inhibiting the p38 MAPK signaling pathway.International Immunopharmacology2019, 66: 146–153.

9. Zhang XY, Li W, Wang J, Li N, Cheng MS, Koike K.Protein tyrosine phosphatase 1B inhibitory activities of ursane-type triterpenes from Chinese raspberry, fruits of Rubuschingii.Chin J Nat Med. 2019, 17(1):15-21. doi: 10.1016/S1875-5364(19)30004-4.

10. Yuan L1, Liu J1, He W2, Bao Y3, Sheng L1, Zou C4, Hu B1, Ge W1, Liu Y1, Wang J1, Lin B1, Li Y5, Ma E6.Discovery of a novel cathepsin inhibitor with dual autophagy-inducing and metastasis-inhibiting effects on breast cancer cells.Bioorg Chem. 2019 Mar;84:239-253. doi: 10.1016/j.bioorg.2018.11.025. Epub 2018 Nov 22.

11. Li Y1,2, Wang C2, Wang J3, Chu T1, Zhao L1,4, Zhao L1,4.Permeation-enhancing effects and mechanisms of O-acylterpineol on isosorbidedinitrate: mechanistic insights based on ATR-FTIR spectroscopy, molecular modeling, and CLSM images.DrugDeliv. 2019 Dec;26(1):107-119. doi: 10.1080/10717544.2018.1561764.

12. Mingxing Wang, Ying Wang, Dejiang Kong, Hailun Jiang, Jian Wang*, Maosheng Cheng. In silico exploration of aryl sulfonamide analogs as voltage-gated sodium channel 1.7 inhibitors by using 3D-QSAR, molecular docking study, and molecular dynamics simulations. Computational Biology and Chemistry, 2018, 77: 214-225.

13. Dandan Li , Changhao Zhao, Huaiwei Ding,  Qiong Wu,  Tianshu Ren,  Jian Wang*, Congqin Chen,  Qingchun Zhao*. A novel inhibitor of ADAM17 sensitizes colorectal cancer cells to 5‐Fluorouracil by reversing Notch and epithelial‐mesenchymal transition in vitro and in vivo. Cell Proliferation, 2018, 51(5): e12480. https://doi.org/10.1111/cpr.12480

14. Lei Yuan, Lei Sheng, Wenhui He, Chunyang Zou, Baichun Hu, Jun Liu, WentaoGe,Yang Liu, Jian Wang*, Enlong Ma*. Discovery of novel cathepsin inhibitors with potent anti-metastatic effects in breast cancer cells. Bioorganic Chemistry 2018, 81: 672-680. DOI: 10.1016/j.bioorg.2018.09.029

15. Ningbo Qin, Tatsunori Sasaki, Wei Li, Jian Wang, Xiangyu Zhang, Dahong Li, Zhanlin Li, Maosheng Cheng, Huiming Hua & Kazuo Koike show. Identification of flavonolignans from Silybummarianum seeds as allosteric protein tyrosine phosphatase 1B inhibitors. J Enzyme Inhib Med Chem. 2018, 33(1):1283-1291. doi: 10.1080/14756366.2018.1497020.

16. LingheZang*, Jian Wang, Yanlin Ren, Weiwei Liu, Yang Yu, Songyan Zhao,WuxiyarOtkur, Yingxi Zhao, Toshihiko Hayashi, Shin-ichiTashiro, Satoshi Onodera,Takashi Ikejima*. Activated toll-like receptor 4 is involved in oridonin-induced phagocytosisvia promotion of migration and autophagy-lysosome pathway in RAW264.7macrophages. International Immunopharmacology.2018, 66: 99-108. DOI: 10.1016/j.intimp.2018.11.014

17. Junning Chen, Hailun Jiang, Fangfei Li, Baichun Hu, Ying Wang, MingXing Wang, Jian Wang*, Maosheng Cheng.Computational insight into dengue virus NS2B-NS3 protease inhibition: Acombined ligand- and structure-based approach. Computational Biology and Chemistry. 2018, 77: 261-271.https://doi.org/10.1016/j.compbiolchem.2018.09.010

18. Mingxing Wang, Wei Li, Ying Wang, Yongbo Song, Jian Wang*, Maosheng Cheng*. In silico insight into voltage-gated sodium channel 1.7 inhibition for anti-pain drug discovery. Journal of Molecular Graphics and Modelling. 2018, 84: 18-28. DOI: 10.1016/j.jmgm.2018.05.006.

19. Xue Liu, Wei Li, Baichun Hu, Mingxing Wang, Jian Wang,* Lijie Guan*.  Identification of isobavachalcone as a potential drug for Rice Blast Disease caused by the fungus Magnaporthegrisea. Journal of Biomolecular Structure and Dynamics. DOI: 10.1080/07391102.2018.1515117. (To be published)

20. Peiyu Zhou, Lingmin Zhang, Wei Li, Shuting Zhang, Lanxin Luo, Jian Wang*, Baoshan Sun*. In vitro evaluation of the anti-digestion and antioxidant effects of grape seed procyanidins according to their degrees of polymerization.Journal of Functional Foods 2018, 49: 85–95. DOI:10.1016/j.jff.2018.08.001.

21. Wei Li, Xue Liu, Suleiman Muhammad, Jiyue Shi, YanqiuMeng*, Jian Wang*. Computational investigation of TGF-β receptor inhibitors for treatment of idiopathic pulmonary fibrosis: Field-based QSAR model and molecular dynamics simulation. Computational Biology & Chemistry2018, 76: 139-150. DOI: 10.1016/j.compbiolchem.2018.07.002

22. Meng Li, Yu Zhao, Li Zhou, Jia Yu, Jian Wang*, XingjieGuo*. Study of the enantiomeric separation of the anticholinergic drugs on two immobilized polysaccharide-based chiral stationary phases by HPLC and the possible chiral recognition mechanisms. Electrophoresis2018, DOI: 10.1002/elps.201800039.

23. Yingying Wu, Yuna Cui, Tianyuan Zhang, Wei Li, Mengyue Zhang, Juan Cheng, Yan Wang, Jian Wang, Yuqing Zhao, Yixuan Zhang. Transformation of ginsenoside Rh4 and its aglycone from the total saponins of stems and leaves of Panax ginseng by Aspergillus tubingensis. Phytochemistry Letters doi.org/10.1016/j.phytol.2018.07.023

24. Fudan Dong, DandanLiu, Chenglong Deng, Xiaochun Qin, KaiChen, Jian Wang, HongRui Song, Huaiwei Ding. Design, synthesis and biological evaluation of novel series of 2H-benzo[b][1,4]oxazin-3(4H)-one and 2H-benzo[b][1,4]oxazine scaffold derivatives as PI3Kα inhibitors. Bioorganic & Medicinal Chemistry 2018, 26(14): 3982-3991. doi.org/10.1016/j.bmc.2018.06.022

25. Huai-Wei Ding, Cheng-Long Deng, Dan-Dan Li, Dan-Dan Liu, Shao-MengChai,Wei Wang, Yan Zhang, Kai Chen, Xin Li, Jian Wang, Shao-Jiang Song,Hong-Rui Song. Design, synthesis and biological evaluation of novel 4-aminoquinazolines as dual target inhibitors of EGFR-PI3Ka. European Journal of Medicinal Chemistry 2018, 146: 460-470

26. ChenzhouHao,Fan Zhao, Hongyan Song, Jing Guo, Xiaodong Li, Xiaolin Jiang, Ran Huan,Shuai Song, Qiaoling Zhang, Ruifeng Wang, Kai Wang, Yu Pang, Tongchao Liu, TianqiLu,Wanxu Huang, Jian Wang, Bin Lin, Zhonggui He, HaitaoLi,Feng Li, DongmeiZhao,andMaosheng Cheng. Structure-Based Design of 6-Chloro-4-aminoquinazoline-2-carboxamide Derivatives as Potent and Selective p21-Activated Kinase 4 (PAK4) Inhibitors.  Journal Medicinal Chemistry 2018, 61(1):265-285. doi: 10.1021/acs.jmedchem.7b01342.

27. Jing Guo, Fan Zhao, Wenbo Yin, Mingyue Zhu, ChenzhouHao, Yu Pang, Tianxiao Wu, Jian Wang, Dongmei Zhao , Haitao Li, Maosheng Cheng, Design, synthesis, structure-activity relationships study and X-ray crystallography of 3-substituted-indolin-2-one-5-carboxamide derivatives as PAK4 inhibitors. European Journal of Medicinal Chemistry, 2018, 155: 197–209

28. Jingkun Lu, Yuchong Hu, Lechun Wang, Yuewu Wang, Shengsang Na, Jian Wang, Yuhui Shun, Xiaoqin Wang, PeifengXue, Pengwei Zhao and Liping Su. Understanding the Multitarget Pharmacological Mechanism of the Traditional Mongolian Common Herb Pair GuangZao-RouDouKou Acting on Coronary Heart Disease Based on a Bioinformatics Approach.Evidence-Based Complementary and Alternative Medicine.2018,7956503. doi: 10.1155/2018/7956503.

29. Lai S, Chen JN, Huang HW, Zhang XY, Jiang HL, Li W, Wang PL, Wang J, Liu FN.Structure activity relationships of chrysoeriol and analogs as dual c‑Met and VEGFR2 tyrosine kinase inhibitors. Oncol Rep. 2018, 40(3):1650-1656. doi: 10.3892/or.2018.6542. Epub 2018 Jul 2.

30. Xiang Yu, YiguangJin* , Lina Du, Mengchi Sun, Jian Wang, Qiu Li, Xiangyu Zhang, Zisen Gao, and Pingtian Ding. Transdermal Cubic Phases of Metformin Hydrochloride: In Silico and in Vitro Studies of Delivery Mechanisms. Mol. Pharmaceutics, 2018, 15 (8), 3121–3132. DOI: 10.1021/acs.molpharmaceut.8b00209.

31. Liu Y1, Zhao D1, Sun M1, Wei W1, Wang Y1, Zhou J1, Zhang R1, Wang J2, Zhang H3, He Z1, Kan Q4,5, Sun J6,7.Covalently mucoadhesive amphiphilic prodrug of 5-fluorouracil for enhanced permeation and improved oral absorption.DrugDelivTransl Res. 2018 Jun;8(3):645-656. doi: 10.1007/s13346-018-0502-z.

32. Zhang L1, Zhao Y1, Wang J1, Yang D1, Zhao C1, Wang C2, Ma C3, Cheng M4.Design, synthesis and bioevaluation of 1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline-1-carboxylic acid derivatives as potent neuroprotective agents.Eur J Med Chem. 2018 May 10;151:27-38. doi: 10.1016/j.ejmech.2018.03.052. Epub 2018 Mar 23.

33. Zhang J, Sasaki T, Li W, Nagata K, Higai K, Feng F, Wang J, Cheng M, Koike K.Identification of caffeoylquinic acid derivatives as natural protein tyrosine phosphatase 1B inhibitors from Artemisia princeps. Bioorg Med Chem Lett. 2018 Apr 15;28(7):1194-1197. doi: 10.1016/j.bmcl.2018.02.052. Epub 2018 Mar 6.

34. Wu T, Pang Y, Guo J, Yin W, Zhu M, Hao C, Wang K, Wang J, Zhao D, Cheng M.Discovery of 2-(4-Substituted-piperidin/piperazine-1-yl)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-quinazoline-2,4-diamines as PAK4 Inhibitors with Potent A549 Cell Proliferation, Migration, and Invasion Inhibition Activity. Molecules. 2018 Feb 14;23(2). pii: E417. doi: 10.3390/molecules23020417.

35. Huang HW, Zhang XY, Song PL, Jiang HL, Li W, Wang PL, Wang J, Liu FN.Old drug new tricks: Chlorhexidine acts as a potential allosteric inhibitor toward PAK1. BiochemBiophys Res Commun. 2018 Jan 1;495(1):728-732. doi: 10.1016/j.bbrc.2017.11.087. Epub 2017 Nov 14.

36. Xiangyu Zhang, Hailun Jiang, Wei Li, Jian Wang*, and Maosheng Cheng*. Computational Insight into Protein Tyrosine Phosphatase 1B Inhibition: A Case Study of the Combined Ligand- and Structure-Based Approach. Computational and Mathematical Methods in Medicine, 2017, 4245613:1-13. doi:10.1155/2017/4245613.

37. Gang Wang, Hongxiang Chen, Dongyang Zhao, Dawei Ding, Mengchi Sun, Longfa Kou, Cong Luo, Dong Zhang, Xiulin Yi, Jinhua Dong, Jian Wang, Xiaohong Liu, Zhonggui He, Jin Sun*.Combination of l-Carnitine with Lipophilic Linkage-Donating Gemcitabine Derivatives as Intestinal Novel Organic Cation Transporter 2-Targeting Oral Prodrugs. J Medicinal Chemistry 2017, 60 (6): 2552–2561. DOI: 10.1021/acs.jmedchem.7b00049.

38. Jian Wang^*, Wei Li, Bo Wang, Baichun Hu,Hailun Jiang, Bate Lai, Ning Li.^.In Silicon Approach for Discovery of Chemopreventive Agents.Current Pharmacology Reports. 2017, 3(4): 184–195. DOI:10.1007/s40495-017-0094-1

39. Maolin Sun , Qile Xu , Jingwen Xu, Yue Wu, Yueting Wang, DaiyingZuo, Qi Guan, Kai Bao, Jian Wang*, Yingliang Wu, Weige Zhang*. Synthesis and bioevaluation of N,4-diaryl-1,3-thiazole-2-amines as tubulin inhibitors with potent antiproliferative activity. Plos one, 2017, 12(3): e0174006.h. DOI: 10.1371/journal.pone.0174006.

40. Jing Li, Xin Wang, Chang Li, Na Fan, Jian Wang, Zhonggui He , and Jin Sun*.  Viewing Molecular and Interface Interactions of Curcumin Amorphous Solid Dispersions for Comprehending Dissolution Mechanisms. Molecular Pharmaceutics, 2017, 14 (8): 2781–2792. DOI: 10.1021/acs.molpharmaceut.7b00319

41. Yaqi Yao, Peilu Song, Xiaoli Wen, Miaoduo Deng, Jian Wang*, XingjieGuo*.Chiral separation of 12 pairs of enantiomers by capillary electrophoresis using heptakis-(2,3-diacetyl-6-sulfato)-�-cyclodextrin as the chiral selector and the elucidation of the chiral recognition mechanism by computational methods. Journal of Separation Science 2017, 40:2999–3007.DOI: 10.1002/jssc.201700137

42. Jing Li, Na Fan, Chang Li, Jian Wang∗, Sanming Li, Zhonggui He∗.The tracking of interfacial interaction of amorphous solid dispersions formed by water-soluble polymer and nitrendipine. Applied Surface Science,2017, 420: 136–144

43. Wei-Hong Zhao, Ning Li*, Yang Chu, Tao Sun, Jian Wang, Wen-Li Wang, Jia-Yuan Li, BinLin, Ru Chen& Yue Hou. Novel cycloneolignans fromVerniciafordiiwith inhibitoryeffects on over-activation of BV2cells in vitro. Scientific Reports, 2017, 7: 13608. DOI: 10.1038/s41598-017-14062-z

44. ChenzhouHao, WanxuHuang, XiaodongLi, JingGuo, MengChen, ZizhengYan, KaiWang, XiaolinJiang, Shuai Song, JianWang, DongmeiZhao, FengLi, MaoshengCheng. Development of 2, 4-diaminoquinazoline derivatives as potent PAK4 inhibitors by the core refinement strategy.Eur J Med Chem. 2017, 131:1-13. doi: 10.1016/j.ejmech.2017.02.063.

45. Fan YH, Li W, Liu DD, Bai MX, Song HR, Xu YN, Lee S, Zhou ZP, Wang J, Ding HW.Design, synthesis, and biological evaluation of novel 3-substituted imidazo[1,2-a]pyridine and quinazolin-4(3H)-one derivatives as PI3Kα inhibitors. Eur J Med Chem. 2017 Oct 20;139:95-106. doi: 10.1016/j.ejmech.2017.07.074. Epub 2017 Aug 1.

46. Zhang S, Sun M, Zhao Y, Song X, He Z, Wang J, Sun J.Molecular mechanism of polymer-assisting supersaturation of poorly water-soluble loratadine based on experimental observations and molecular dynamic simulations. Drug DelivTransl Res. 2017 Oct;7(5):738-749. doi: 10.1007/s13346-017-0401-8.

47. Kou L, Yao Q, Sun M, Wu C, Wang J, Luo Q, Wang G, Du Y, Fu Q, Wang J, He Z, Ganapathy V, Sun J.Cotransporting Ion is a Trigger for Cellular Endocytosis of Transporter-Targeting Nanoparticles: A Case Study of High-Efficiency SLC22A5 (OCTN2)-Mediated Carnitine-Conjugated Nanoparticles for Oral Delivery of Therapeutic Drugs. AdvHealthc Mater. 2017 Sep;6(17). doi: 10.1002/adhm.201700165. Epub 2017 Jun 29.

48. Wang Q, Ma W, Tong Q, Du G, Wang J, Zhang M, Jiang H, Yang H, Liu Y, Cheng M. Graphene Oxide Foam Supported Titanium(IV): Recoverable Heterogeneous Catalyst for Efficient, Selective Oxidation of Arylalkyl Sulfides to Sulfoxides Under Mild Conditions.Sci Rep. 2017 Aug 3;7(1):7209. doi: 10.1038/s41598-017-07590-1.

49. Guo J, Zhu M, Wu T, Hao C, Wang K, Yan Z, Huang W, Wang J, Zhao D, Cheng M. Discovery of indolin-2-one derivatives as potent PAK4 inhibitors: Structure-activity relationship analysis, biological evaluation and molecular docking study.Bioorg Med Chem. 2017 Jul 1;25(13):3500-3511. doi: 10.1016/j.bmc.2017.04.047. Epub 2017 May 3.

50. Yao Y, Song P, Wen X, Deng M, Wang J, Guo X. Chiral separation of 12 pairs of enantiomers by capillary electrophoresis using heptakis-(2,3-diacetyl-6-sulfato)-β-cyclodextrin as the chiral selector and the elucidation of the chiral recognition mechanism by computational methods.J Sep Sci. 2017 Jul;40(14):2999-3007. doi: 10.1002/jssc.201700137.

51. Qin NB, Li SG, Yang XY, Gong C, Zhang XY, Wang J, Li DH, Guo YQ, Li ZL, Hua HM.Bioactiveterpenoids from Silybummarianum and their suppression on NO release in LPS-induced BV-2 cells and interaction with iNOS.Bioorg Med Chem Lett. 2017 May 15;27(10):2161-2165. doi: 10.1016/j.bmcl.2017.03.058. Epub 2017 Mar 24.

52. Li FR, Fan ZF, Qi SJ, Wang YS, Wang J, Liu Y, Cheng MS. Design, Synthesis, Molecular Docking Analysis, and Carbonic Anhydrase IX Inhibitory Evaluations of Novel N-Substituted-β-d-Glucosamine Derivatives that Incorporate Benzenesulfonamides.Molecules. 2017 May 12;22(5). pii: E785. doi: 10.3390/molecules22050785.

53. Hou Y, Li G, Wang J, Pan Y, Jiao K, Du J, Chen R, Wang B, Li N.Okanin, effective constituent of the flower tea Coreopsis tinctoria, attenuates LPS-induced microglial activation through inhibition of the TLR4/NF-κB signaling pathways. Sci Rep. 2017 Apr 3;7:45705. doi: 10.1038/srep45705.

54. Ning-Bo Qin, Sheng-Ge Li, Xue-Yuan Yang, Chi Gong, Xiang-Yu Zhang, Jian Wang*,Da-Hong Li, Yuan-QiangGuo, Zhan-Lin Li, Hui-Ming Hua*. Bioactive terpenoids from Silybummarianum and their suppression on NO release in LPS-induced BV-2 cells and interaction with iNOS.Bioorganic & Medicinal Chemistry Letters 2017, 27: 2161–2165.

55. Fan Y, Liu J, Liu D, Zhou Z, Bao Y, Wang J, Zhao Q, Xu Y.NSCA-1-a novel N-substituted coumalamide derivative-increases Adriamycin sensitivity in HepG2/adriamycin cells through modulating Akt/GSK-3β signaling and p53-dependant apoptotic pathway.  Environ ToxicolPharmacol. 2017 Jan;49:1-7. doi: 10.1016/j.etap.2016.09.012. Epub 2016 Sep 22.

56. Mengchi Sun, Chunnuan Wu, Qiang Fu, Donghua Di, Xiao Kuang, Chao Wang, Zhonggui He, Jian Wang*,Jin Sun*. Solvent-shift strategy to identify suitable polymers to inhibit humidity-induced solid-state crystallization of lacidipine amorphous solid dispersions. International Journal of Pharmaceutics, 2016, 503(1-2): 238-246. DOI: 10.1016/j.ijpharm.2016.01.062.

57. Shuai Zhao, YuichiroKanno, Wei Li; Tatsunori Sasaki, XiangyuZhang, Jian Wang, MaoshengCheng, Kazuo Koike, KiyomitsuNemoto,Huicheng Li. Identification of picrasidine C as a subtype-selective PPARα agonist. Journal of Natural Products, 2016, 79 (12): 3127–3133,  DOI: 10.1021/acs.jnatprod.6b00883

58. ChenzhouHao, Xiaodong Li, Shuai Song, BingyuGuo, Jing Guo, Jian Wang, Bin Lin, Maosheng Cheng, Feng Li, Dongmei Zhao.Design, synthesis and biological evaluation of 1-phenanthryl-tetrahydroisoquinoline derivatives as novel p21-activated kinase 4 (PAK4) inhibitors.Organic &Biomolecular Chemistry, 2016, 14(32):7676-90. doi: 10.1039/c6ob01072e.

59. Jian Zhang, Hong-Yan Zhang, Jian Wang, Liang-Hao You, Rui-Zhi Zhou, Dong-Mei Zhao, Mao-Sheng Cheng and Feng Li,* GL-1196 Suppresses the Proliferation and Invasion of Gastric Cancer Cells via Targeting PAK4 and Inhibiting PAK4-Mediated Signaling Pathways. International Journal of Molecular Sciences. 2016, 17(4), 470; https://doi.org/10.3390/ijms17040470.

60. Wang W, Li N, Wang J, Chen G, Huang R, Zhao W, Li J, Si Y. Bioactive benzofuran-chalcanes as potential NQO1 inducers from Millettiapulchra (Benth) kurzvar-laxior (Dunn) Z.Wei.Phytochemistry. 2016 Nov;131:107-114. doi: 10.1016/j.phytochem.2016.09.005. Epub 2016 Sep 20.

61. Li LZ, Liang X, Sun X, Qi XL, Wang J, Zhao QC, Song SJ. Bioactive norditerpenoids and neolignans from the roots of salvia miltiorrhiza.Org Biomol Chem. 2016 Oct 25;14(42):10050-10057.

62. Yin T, Cao X, Liu X, Wang J, Shi C, Su J, Zhang Y, Gou J, He H, Guo H, Tang X, Zhao Y. Interfacial molecular interactions based on the conformation recognition between the insoluble antitumor drug AD-1 and DSPC.Colloids Surf B Biointerfaces. 2016 Oct 1;146:902-9. doi: 10.1016/j.colsurfb.2016.07.040. Epub 2016 Jul 20.

63. Wen J, Bao Y, Niu Q, Liu J, Yang J, Wang W, Jiang T, Fan Y, Li K, Wang J, Zhao L, Liu D. Synthesis, biological evaluation and molecular modeling studies of psammaplin A and its analogs as potent histone deacetylases inhibitors and cytotoxic agents.Bioorg Med Chem Lett. 2016 Sep 1;26(17):4372-6. doi: 10.1016/j.bmcl.2015.12.094. Epub 2015 Dec 29.

64. Shi X, Zhang G, Mackie B, Yang S, Wang J, Shan L. Comparison of the in vitro metabolism of psoralidin among different species and characterization of its inhibitory effect against UDP- glucuronosyltransferase (UGT) or cytochrome p450 (CYP450) enzymes.JChromatogr B AnalytTechnol Biomed Life Sci. 2016 Sep 1;1029-1030:145-156. doi: 10.1016/j.jchromb.2016.06.031. Epub 2016 Jun 30.

65. Hao C, Li X, Song S, Guo B, Guo J, Zhang J, Zhang Q, Huang W, Wang J, Lin B, Cheng M, Li F, Zhao D. Advances in the 1-phenanthryl-tetrahydroisoquinoline series of PAK4 inhibitors: potent agents restrain tumor cell growth and invasion.Org Biomol Chem. 2016 Aug 10;14(32):7676-90. doi: 10.1039/c6ob01072e.

66. Wang KB, Li DH, Hu P, Wang WJ, Lin C, Wang J, Lin B, Bai J, Pei YH, Jing YK, Li ZL, Yang D, Hua HM. A Series of β-Carboline Alkaloids from the Seeds of Peganumharmala Show G-Quadruplex Interactions.Org Lett. 2016 Jul 15;18(14):3398-401. doi: 10.1021/acs.orglett.6b01560. Epub 2016 Jun 24.

67. Dai X, Jia X, Zhao P, Wang T, Wang J, Huang P, He L, Hou X. A combined experimental/computational study on metal-organic framework MIL-101(Cr) as a SPE sorbent for the determination of sulphonamides in environmental water samples coupling with UPLC-MS/MS.Talanta. 2016 Jul 1;154:581-8. doi: 10.1016/j.talanta.2016.03.042. Epub 2016 Mar 24.