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袁雷 Teacher Profile

 

姓名:袁雷

性别:男

籍贯:辽宁省辽阳市

联系电话:18341435509

E-Mail:leiyuan@syphu.edu.cn

职称/职务:副教授

通讯地址:

办公地点:制药楼209

教育经历:

(1) 2005.92010.3, 沈阳药科大学, 药物化学, 博士;

(2) 2002.92005.7, 辽宁大学, 有机化学 , 硕士;

(3) 1998.92002.7, 辽宁大学, 化学, 学士

工作经历:

(1) 2016.12-2017.12, 克利夫兰州立大学, 化学系, 访问学者;

(2) 2010.3-至今, 沈阳药科大学, 制药工程

兼职情况:

学科/研究方向:药物化学/新颖作用机制抗肿瘤药物开发及抗纤维化药物开发

科研/获奖情况:

教学/指导研究生情况: 负责本科生《药物化学》《有机合成化学》课程的讲授,目前已协助指导硕士研究生10人,毕业5人。

发表论文/出版著作:

代表性著作:

12011年版新大纲国家执业药师资格考试指南药学专业知识(二),人民卫生出版社,副主编 4/107.7/87()

2药物合成反应实验(双语),中国医药科技出版社,参编4/41.5/9()

代表性论文:

(1) Lei Yuan, Jun Liu, Wenhui He, Youmei Bao, Lei Sheng, Chunyang Zou, Baichun Hu, Wentao Ge, Yang Liu, Jian Wang, Bin Lin, Yanchun Li, Enlong Ma*. Discovery of a novel cathepsin inhibitor with dual autophagy-inducing and metastasis-inhibiting effects on breast cancer cells. Bioorganic Chemistry, 2019, 84, 239–253.

(2) Lei Yuan, Lei Sheng, Wenhui He, Chunyang Zou, Baichun Hu, Jun Liu, Wentao Ge, Yang Liu, Jian Wang, Enlong Ma*. Discovery of novel cathepsin inhibitors with potent anti-metastatic effects in breast cancer cells. Bioorganic Chemistry, 2018, 81, 672–680.

(3) Qingyin Liu, Wei Li, Lei Sheng, Chunyang Zou, Hongxin Sun, Chunfeng Zhang, Yang Liu, Jiyue Shi, Enlong Ma, Lei Yuan*. Design, synthesis and biological evaluation of novel asperphenamate derivatives. European Journal of Medicinal Chemistry, 2016, 110, 76–86.

(4) Lei Yuan, Yanchun Li, Chunyang Zou, Chao Wang, Jian Gao, Caixia Miao, Enlong Ma, Tie-min Sun.Synthesis and in vitro antitumor activity of asperphenamate derivatives as autophagy inducer. Bioorganic and Medicinal Chemistry Letters, 2012, 22(6), 2215–2219.

(5) Lei Yuan, Jin-hui Wang, Tie-min Sun. Total synthesis and anticancer activity studies of the stereoisomers of asperphenamate and patriscabratine. Chinese Chemical Letters, 2010, 21(2), 155–158.

(6)袁雷,杨元帅,王志强,王健,孙铁民。天然产物共同药效团导向patriscabratine 的抗肿瘤活性。沈阳药科大学学报201229(11)852–855

(7)袁雷,李云飞。Asperphenamate 衍生物的合成及体外抗乳腺癌活性评价。中国药物化学杂志2010, 20(5), 336341

(8) Yanchun Li, Qiyu Luo, Lei Yuan, Caixia Miao, Xiaoshuo Mu, Wei xiao, Jianchun Li, Enong Ma. JNK-dependent Atg4 upregulation mediates asperphenamate derivative BBP-induced autophagy in MCF-7 cells. Toxicology and Applied Pharmacology, 2012, 263(1), 2131.

会议论文:

(1) Lei Yuan*, Jian Wang, Enlong Ma. Discovery of novel cathepsin inhibitors by natural product consensus pharmacophore strategy. 11th International Symposium for Chinese Medicinal Chemists, Zhengzhou, August 24th-26th, 2018.

(2) Lei Sheng, Qingyin Liu, Hongxin Sun, Chunfeng Zhang, Yang Liu, Lei Yuan*.Synthesis of autophagy inducer based on asperphenamate scaffold. 9th International Symposium for Chinese Medicinal Chemists, Shenyang, August 17th-20th, 2014.

三、授权发明专利

1.袁雷,马恩龙,谢集照。N, N’-苯丙氨基酸苯丙氨基醇类衍生物及其制备方法。公开号:ZL200810010040.9

2.袁雷,马恩龙,何文慧。组织蛋白酶抑制剂及其制备方法和应用,申请号:201611230425.7

3.袁雷,马恩龙。组织蛋白酶抑制剂及其制备方法和应用,申请号:201810905792.5

 

 

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