姓名：程卯生
性别：男
籍贯：内蒙古
联系电话：18304014230
E-Mail：mscheng@syphu.edu.cn
职称/职务：教授
通讯地址：沈阳药科大学
办公地点：制药楼225
教育经历：
1981-1985 沈阳药科大学，工学学士
1985-1988 沈阳药科大学，理学硕士
1988-2001 沈阳药科大学，理学博士
工作经历：
1988-1990 沈阳药学院药学系药物化学教研室，助教
1991-1993 沈阳药学院药物研究所，助理研究员
1993-1998 沈阳药学院药物研究所，副研究员
1995-1997 美国加州大学旧金山分校药学院，访问学者
1998-2001 沈阳药科大学制药工程学院，教授
2002-2004 沈阳药科大学制药工程学院，校长助理兼院长
2005-2010 沈阳药科大学，校长助理兼国际交流处处长
2010至今 沈阳药科大学，副校长
兼职情况：
2007至今 亚洲药物化学联盟理事会，理事
2007至今 中国药学会第22届、第23届、第24届理事会，理事
2007-2015 中国药学会第22、第23届药物化学专业委员会，副主任委员
2017至今 中国药学会第24届国际交流委员会，副主任委员
2010-2014 国家自然科学基金第13届、第14届专家评审组，委员
2001至今 《中国药物化学杂志》, 执行主编
学科/研究方向：药物化学/计算机辅助药物设计
科研/获奖情况：
2016.05 获全国优秀科技工作者荣誉称号
2015.12 《奥美拉唑系列产品产业化和国际化关键技术》获国家科学技术进步奖二等奖
2012.10 入选第一批“辽宁特聘教授”
2010.03 获“辽宁省高层次科技专家库专家”称号
2007.01 《抗消化性溃疡药物的研究》获教育部科学技术进步奖二等奖
2006.12 入选“新世纪百千万人才工程”国家级人选
2005.10 获“辽宁省优秀专家”称号
2004.10 获国务院特殊津贴
2003.12 《吡啶衍生物的制备方法》获中国专利优秀奖
2000.06 教育部首届青年教师奖
1994.10 吴阶平医学研究奖和保罗·杨森药学研究奖药物化学专业二等奖
1994.04 获国家"中青年有突出贡献专家"称号
1992.01 《法莫替丁原料药及其制剂的研究》获国家医药管理局科学技术进步奖二等奖
教学/指导研究生情况： 《药物化学专论》
发表论文/出版著作： 发表SCI收录论文200篇。
代表性著作：
主编，《医药伦理学》（普通高等教育“十一五”规划教材），中国医药科技出版社，2008年3月第二版
主编，《医药伦理学》（全国高等医药院校药学类规划教材），中国医药科技出版社，2002年4月第一版
主编，《药物研究与开发》，人民卫生出版社，2007年1月第一版
代表性论文：
1. Chenzhou Hao, Wanxu Huang, Xiaodong Li, Jing Guo, Meng Chen, Zizheng Yan, Kai Wang, Xiaolin Jiang, Shuai Song, Jian Wang, Dongmei Zhao, Feng Li, Maosheng Cheng*.Development of 2, 4-diaminoquinazoline derivatives as potent PAK4 inhibitors by the core refinement strategy. European Journal of Medicinal Chemistry, 2017, 131:1-13.
2. Wenxi Ma, Qiaoling Tong, Jian Wang, Huali Yang, Meng Zhang, Hailun Jiang, Qinghe Wang, Yongxiang Liu, Maosheng Cheng*. Synthesis and characterization of titanium(IV)/graphene oxide foam: a sustainable catalyst for the oxidation of benzyl alcohol to benzaldehyde. RSC Advances, 2017(11): 6720-6723.
3. Yongxiang Liu, Shengfei Jin, Yanshi Wang, Shanshan Cui, Xiaoshi Peng, Yuanyuan Niu, Chuan Du, Maosheng Cheng*. A gold (I)-catalyzed substituent-controlled cycloisomerization of propargyl vinyl ethers to multi-substituted furofuran and furopyran derivatives. Chemical Communications, 2016, 52(37): 6233-6236.
4. Chenzhou Hao, Xiaodong Li, Shuai Song, Bingyu Guo, Jing Guo, Jian Zhang, Qiaoling Zhang, Wanxu Huang, Jian Wang, Bin Lin, Maosheng Cheng*, Feng Li, Dongmei Zhao. Advances in the 1-phenanthryl-tetrahydroisoquinoline series of PAK4 inhibitors: potent agents restrain tumor cell growth and invasion. Organic & Biomolecular Chemistry, 2016, 14(32): 7676-7690.
5. Chongguo Jiang, Zhiling Xiong, Shengfei Jin, Peng Gao, Yingzhan Tang, Yanshi Wang, Chuan Du, Xiaoyu Wang, Yang Liu, Bin Lin, Yongxiang Liu, Maosheng Cheng*. A Au (I)-catalyzed hydrogen bond-directed tandem strategy to synthesize indeno-chromen-4-one and indeno-quinolin-4-one derivatives. Chemical Communications, 2016, 52(77): 11516-11519.
6. Shengfei Jin, Chongguo Jang, Xiaoshi Peng, Chunhui Shan, Shanshan Cui, Yuanyuan Niu, Yang Liu, Yu Lan, Yongxiang Liu, Maosheng Cheng*. Gold (I)-Catalyzed Angle Strain Controlled Strategy to Furopyran Derivatives from Propargyl Vinyl Ethers: Insight into the Regioselectivity of Cycloisomerization. Organic Letters, 2016, 18(4): 680-683.
7. Gaofei Wei, Shanshan Cui, Weijing Luan, Shuai Wang, Zhuang Hou, Yongxiang Liu, Yang Yang, Maosheng Cheng*. Natural product-based design, synthesis and biological evaluation of Albiziabioside A derivatives that selectively induce HCT116 cell death. European Journal of Medicinal Chemistry, 2016, 113: 92-101.
8. Xiaoyu Wang, Chuan Du, Hui Shi,Yadong Pang, Shengfei Jin, Yuqian Hou, Yanshi Wang, Xiaoshi Peng, Jianyong Xiao, Yang Liu, Yongxiang Liu, Mao-Sheng Cheng*. Fe (III)-catalyzed trityl benzyl ether formation and disproportionation cascade reactions to yield benzaldehydes. Tetrahedron, 2015, 71(38): 6744-6748.
9. Yongxiang Liu, Xiaoyu Wang, Yanshi Wang, Chuan Du, Hui Shi, Shengfei Jin, Chongguo Jiang, Jianyong Xiao, Maosheng Cheng*. Gold (I)-Catalyzed Synthesis of Unsymmetrical Ethers Using Alcohols as Alkylating Reagents. Advanced Synthesis & Catalysis, 2015, 357(5): 1029-1036.
10. Gaofei Wei, Weijing Luan, Shuai Wang, Shanshan Cui, Fengran Li, Yongxiang Liu, Yang Liu, Maosheng Cheng*. A library of 1, 2, 3-triazole-substituted oleanolic acid derivatives as anticancer agents: design, synthesis, and biological evaluation. Organic & Biomolecular Chemistry, 2015, 13(5): 1507-1514.
11. Shuai Song, Xiaodong Li,Jing Guo, Chenzhou Hao, Yan Feng, Bingyu Guo, Tongchao Liu, Qiaoling Zhang, Zhen Zhang, Ruijuan Li, Jian Wang, Bin Lin, Feng Li, Dongmei Zhao, Maosheng Cheng*. Design, synthesis and biological evaluation of 1-phenanthryl-tetrahydroisoquinoline derivatives as novel p21-activated kinase 4 (PAK4) inhibitors. Organic & Biomolecular Chemistry, 2015, 13(12): 3803-3818.
12. Ruijuan Li, Xiaolin Su, Zheng Chen, Wanxu Huang, Yali Wang, Kaibo Wang, Bin Lin, Jian Wang, Maosheng Cheng*. Structure-based virtual screening and ADME/T-based profiling for low molecular weight chemical starting points as p21-activated kinase 4 inhibitors. RSC Advances, 2015, 5(30): 23202-23209.
13. Gaofei Wei, Shuai Wang, Shanshan Cui, Jia Guo, Yongxiang Liu, Yang Liu, Maosheng Cheng*. Synthesis and evaluation of the anticancer activity of albiziabioside A and its analogues as apoptosis inducers against human melanoma cells. Organic & Biomolecular Chemistry. 2014, 12(31): 5928–5935.
14. Yongxiang Liu, Jia Guo, Yang Liu, Xiaoyu Wang, Yanshi Wang, Xinyu Jia, Gaofei Wei, Lizhu Chen, Jianyong Xiao, Maosheng Cheng*. Au(I)-catalyzed triple bond alkoxylation/dienolether aromaticity-driven cascade cyclization to naphthalenes. Chemical Communications, 2014, 50(47): 6243–6245.
15. Fengrong Li, Dongmei Zhao, Jinhong Ren, Feiyue Hao, Guyue Liu, Shengfei Jin, Yongkui Jing, Mao-Sheng Cheng*. 2-(2-Methylfuran-3-carboxamido)- 3-phenylpropanoic acid, a potential CYP26A1 inhibitor to enhance all-trans retinoic acid-induced leukemia cell differentiation based on virtual screening and biological evaluation. Bioorganic & Medicinal Chemistry, 2013, 21(11): 3256–3261.
16. Hong-Bo Xie, Yu Sha, Jian Wang, Mao-Sheng Cheng*. Some insights into the binding mechanism of the GABAA receptor: a combined docking and MM-GBSA study. Journal of Molecular Modeling, 2013, 19(12): 5489–5500.
17. Bo Wang, Yang Liu, Yanshi Wang, Xin Liu, Mao-Sheng Cheng*. Syntheses and structure–activity relationship studies of N-substituted-b-D-glucosaminides as selective cytotoxic agents. Bioorganic & Medicinal Chemistry Letters, 2012, 22(23): 7110–7113.
18. Jian Wang, Shao-Jie Wang, Dan-Dan Song, Yong-Kui Jing, Mao-Sheng Cheng*. Quinolinoneacetic acid derivatives as novel glutathione S-transferase P1-1 inhibitors: insights into the interaction modes by molecular modeling. Medicinal Chemistry Research, 2012, 21(10): 2823–2826.
19. Na Yang, Jian Wang, Zhi-Wei Wang, Qing-He Wang, Hong-Guang Yang, Xiu-Jun Wang, Mao-Sheng Cheng*. Computational Insights into the Inhibition of Inosine 5’-Monophosphate Dehydrogenase by Mycophenolic Acid Analogs: Three-Dimensional Quantitative Structure–Activity Relationship and Molecular Docking Studies. Chemical Biology & Drug Design, 2012, 79(5): 1063–1067.
20. Bo Wang, Jaemoo Chun, Yang Liu, Lina Han, Yan-shi Wang, Eun-Ji Joo, Yeong-Shik Kim, Mao-sheng Cheng*. Synthesis of novel diosgenyl saponin analogues and apoptosis-inducing activity on A549 human lung adenocarcinoma. Organic & Biomolecular Chemistry, 2012, 10(44): 8822–8834.
21. Na Yang, Qing-He Wang, Wen-Qian Wang, Jian Wang, Feng Li, Shen-Peng Tan, Mao-Sheng Cheng*. The design, synthesis and in vitro immunosuppressive evaluation of novel isobenzofuran derivatives. Bioorganic & Medicinal Chemistry Letters, 2012, 22(1): 53–56.
22. Xiu-Jun Wang, Na-Ying Chu, Qin-He Wang, Chao Liu, Chun-guo Jiang, Xiao-Yu Wang, Takashi Ikejima, Mao-Sheng Cheng*. Newly synthesized bis-benzimidazole derivatives exerting anti-tumor activity through induction of apoptosis and autophagy. Bioorganic & Medicinal Chemistry Letters, 2012, 22(22): 6297–6300.
23. Na Yang, Jian Wang, Jian Li, Qing-HeWang, Yu Wang, Mao-Sheng Cheng*. A three-dimensional pharmacophore model for IMPDH inhibitors. Chemical Biology & Drug Design, 2011, 78(1): 175–182.
24. Jian Wang, Maocai Yan, Dongmei Zhao, Yu Sha, Feng Li, Mao-Sheng Cheng*. Pharmacophore identification of PAK4 inhibitors. Molecular Simulation, 2010, 36(1): 53–57.
25. Yan-Hui Yang, Mao-Sheng Cheng*, Qing-He Wang, Han Nie, Na Liao, Jian Wang, Hong Chen. Design, synthesis, and anti-tumor evaluation of novel symmetrical bis-benzimidazoles. European Journal of Medicinal Chemistry, 2009, 44(4): 1808–1812.
26. Xin-Ze Cai, Jian Wang, Xiao-Dong Li, Gui-Ling Wang, Fu-Nan Liu, Mao-Sheng Cheng*, Feng Li. Curcumin suppresses proliferation and invasion in human gastric cancer cells by downregulation of PAK1 activity and cyclin D1 expression. Cancer Biology & Therapy, 2009, 8(14): 1360–1368.
27. Jinhong Ren, Xuqiong Xiong, Yu Sha, Maocai Yan, Bin Lin, Jian Wang, Yiongkui Jing, Dongmei Zhao, Maosheng Cheng*. Structure prediction and R115866 binding study of human CYP26A1: homology modelling, fold recognition, molecular docking and MD simulations. Molecular Simulation, 2008, 34(3): 337–346.
28. Kai Bao, Weige Zhang, Xiujuan Bu, Zhichun Song, Liang Zhang, Maosheng Cheng*. A novel type of N-formylation and related reactions of amines via cyanides and esters as formylating agents. Chemical Communications, 2008, 42, 5429–5431.
29. Mao-Cai Yan, Yu Sha, Jian Wang, Xu-Qiong Xiong, Jin-Hong Ren, Mao-Sheng Cheng*. Molecular dynamics simulations of HIV-1 protease monomer: Assembly of N-terminus and C-terminus into β-sheet in water solution. Proteins: Structure, Function, and Bioinformatics, 2008, 70(3): 731–738.
30. Yang Liu, Dong-Mei Zhao, Xue-Hua Lu, Hui Wang, Hong Chen, Ying Ke, Ling Leng, Mao-Sheng Cheng*. Synthesis of bisdesmosidic kryptogenyl saponins using the ‘random glycosylation’ strategy and evaluation of their antitumor activity. Bioorganic & Medicinal Chemistry Letters, 2007, 17(1): 156–160.
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